This study evaluated the effects of immediately treating a developing hospital acquired deep tissue injury with medical honey dressing and air-fluidized therapy, in addition to routine preventative care. Examining 41 DTIs over the course of 18 months, only 4.4% deteriorated to unstageable full thickness wounds, while 46.3% of DTIs were resolved or only progressed to Stage II. Utilization of this protocol resulted in a net savings of approximatley 3 million dollars related to the 39 DTIs that did not deteriorate.